Solvent-free microwave multicomponent regiospecific synthesis of pyrimido[4,5-c]isoquinolines and evaluation in vitro of their antifungal properties was written by Quiroga, Jairo;Cisneros, Carlos;Insuasty, Braulio;Abonia, Rodrigo;Nogueras, Manuel;Sortino, Maximiliano;Zacchino, Susana. And the article was included in Journal of Heterocyclic Chemistry in 2006.Recommanded Product: 54030-56-7 This article mentions the following:
The solvent-free multicomponent reaction of 6-aminopyrimidin-4(3H)-ones with dimedone and N,N-dimethylformamide dimethylacetal under microwave irradiation yields pyrimido[4,5-c]isoquinolinones. In this process, the intermediate of cyclization was isolated. The structure of the synthesized compounds was determined on the basis of NMR measurements, especially by 1H,1H-, 1H ,13C COSY, and DEPT. These compounds showed antifungal in vitro activity particularly against dermatophytes. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Recommanded Product: 54030-56-7).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Recommanded Product: 54030-56-7
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia