Rajasekaran, S. published the artcileSynthesis and anti-denaturation activity of some substituted quinazolinone analogs, Safety of 2-Amino-4,6-dichloropyrimidine, the publication is International Journal of ChemTech Research (2012), 4(3), 1207-1211, database is CAplus.
In recent years there is a tremendous increase of inflammatory cases, leading to the design and development of newer anti-inflammatory agents. The reaction of 2-substituted phenyl-3-chloroacetamido quinazolin-4(3H)-ones with various 5-phenyl-1,3,4-oxadiazole-2-thiol and 5-(pyridine-4-yl)-1,3,4-oxadiazole-2-thiol gave N-(4-oxo-2-substituted phenylquinazolin-3(4H)-yl)-2-[(5-aryl-1,3,4-oxadiazol-2-yl)sulfanyl] acetamides derivatives The reaction of 2-phenyl-3-chloroacetamido quinazolinone with various heteroaryl thiols and amines gave N-(4-oxo-2-Ph quinazolin-3(4H)-yl)-2-[(substituted amino/thiol)] acetamide derivatives The structure of all the compounds has been confirmed by IR, 1HNMR, Mass spectral data and elemental anal. In vitro anti-inflammatory activity was performed by bovine serum albumin method. Some of the compounds have shown good antibacterial activity and few have shown moderate antioxidant activity compared to the standard drug.
International Journal of ChemTech Research published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Safety of 2-Amino-4,6-dichloropyrimidine.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia