The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine.
Raji, Mounir;Le, Tam Minh;Huynh, Thu;Szekeres, Andras;Nagy, Viktoria;Zupko, Istvan;Szakonyi, Zsolt research published 《 Divergent Synthesis, Antiproliferative and Antimicrobial Studies of 1,3-Aminoalcohol and 3-Amino-1,2-Diol Based Diaminopyrimidines》, the research content is summarized as follows. A series of novel diaminopyrimidines containing pinane moieties were synthesized via an efficient methodol. starting from pinane-based aminoalcs., aminodiols and 2,4-dichloropyrimidines. Bioassay tests demonstrated that compound I displayed much stronger antiproliferative activities against four human cancer cell lines (HeLa, Siha, MDA-MB-231, MCF-7 and A2780) than pos. control cisplatin. In particular, compound II was found to be selective in inhibiting HeLa cell proliferation with cancer cell growth inhibition values higher than 95%. Moreover, the in vitro screening of prepared compounds against different bacterial and fungal strains is reported. The results revealed that III and IV, the most promising compounds, displayed selective inhibition for the Gram-pos. bacteria (B. subtilis and S. aureus) with percent inhibition values ranging from 75 to 95% at 10μg/mL concentration Both selective inhibition and the in vitro activity values demonstrated that these compounds have the potential to be developed into clin. important therapeutic choices for the treatment of infections caused by B. subtilis and S. aureus.
Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia