Raju, I. V. Soma published the artcileA stability indicating LC method for lopinavir, Safety of (S)-3-Methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoic acid, the main research area is lopinavir determination reverse phase liquid chromatog.
An isocratic reverse phase liquid chromatog. (RP-LC) assay method was developed for the quant. determination of lopinavir in bulk drug and in pharmaceutical dosage form, used to treat antiviral. The developed method is also applicable for the related substances determination The chromatog. separation was achieved on Agilent Zorbax SB-C18 250 × 4.6 mm, 5 μm. The LC method employs solution A as mobile phase. The solution A contains a mixture of phosphate buffer pH 4.0: acetonitrile (55:45, volume/volume). The flow rate was 1.5 mL/min-1 and the detection wavelength was 210 nm. In the developed HPLC method the resolution between lopinavir and its potential impurities Imp-1, Imp-2, Imp-3, and Imp-4 is >10.0. The drug was subjected to stress conditions of hydrolysis, oxidation, photolysis, and thermal degradation Considerable degradation occurs in thermal, UV, acid medium, and oxidative stress conditions. The stress samples were assayed against a qualified reference standard and the mass balance was found close to 99.7%. The developed RP-LC method was validated with respect to linearity, accuracy, precision, and robustness.
Analytical Chemistry: An Indian Journal published new progress about Drug delivery systems. 192725-50-1 belongs to class pyrimidines, name is (S)-3-Methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoic acid, and the molecular formula is C9H16N2O3, Safety of (S)-3-Methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoic acid.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia