The author of 《Synthesis and Spectral Characterization of New Bis(2-(pyrimidin-2-yl)ethoxy)alkanes and Their Pharmacological Activity》 were Rani, Vangavaragu Jhansi; Aminedi, Raghavendra; Polireddy, Kishore; Jagadeeswarareddy, Kanala. And the article was published in Archiv der Pharmazie (Weinheim, Germany) in 2012. Name: Ethyl 2-(pyrimidin-2-yl)acetate The author mentioned the following in the article:
The pyrimidine nucleus is an important component of nucleic acids (DNA and RNA) and vitamins (B2 and folic acid). It is evident from the literature that pyrimidine derivatives possess a wide spectrum of biol. activities such as antioxidant, anticancer, antibacterial, and anti-inflammatory activities. On the basis of diverse biol. activities, the authors attempted to synthesize a series of novel bis(2-(pyrimidin-2-yl)ethoxy)alkanes 5a-j in four steps with good yields. 2-Chloropyrimidine (1) was reacted with di-Et malonate in the presence of sodium hydride in dry DMF to yield the intermediate di-Et 2-(pyrimidin-2-yl)malonate (2), which on further reaction with sodium chloride and DMSO yielded Et 2-(pyrimidin-2-yl)ethanoate (3). Reduction with sodium borohydride (NaBH4) resulted in the formation of 2-(pyrimidin-2-yl)ethanol (4). This was further reacted with various dibromoalkanes to obtain the title compounds 5a-j. Next, the authors evaluated the antioxidant properties of the title compounds using four in vitro test systems: the 2,2-diphenyl-2-picrylhydrazyl radical-, superoxide radical-, and hydroxyl radical-scavenging assays, and the anti-lipid peroxidation activity test. The title compounds showed promising antioxidant activity when compared to butylated hydroxytoluene. The potency of their antioxidant activity was mainly influenced by the alkyl fragment attached to 2-(pyrimidin-2-yl)ethanol. The Et and Bu fragments linked to oxygen led to increased antioxidant activity of the title compounds (i.e., 5b and 5d) in all the in vitro assays. The results came from multiple reactions, including the reaction of Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3Name: Ethyl 2-(pyrimidin-2-yl)acetate)
Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Name: Ethyl 2-(pyrimidin-2-yl)acetate
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia