Rao, P. Surya Prakash published the artcileA validated chiral LC method for enantiomeric separation of intermediate of lopinavir by using cellulose based chiral stationary phase, Product Details of C9H16N2O3, the main research area is lopinavir intermediate enantiomer chiral HPLC.
A rapid isocratic chiral LC method was developed for the separation of 2R-(1-Tetrahydro pyrimid-2-onyl)-3-Me butanoic acid (R-THPA) from 2S-(1-Tetrahydro pyrimid-2-onyl)-3-Me butanoic acid. (S-THPA). Good resolution with Rs > 3 was obtained using cellulose based chiral stationary phase, chiralcel OD-H column (250 × 4.6 mm, 5 μm particle size) and n-hexane, ethanol and trifluoroacetic acid (900:100:2, volume/volume) as the mobile phase at ambient temperature Flow rate was kept at 1.2 mL/min-1 and elution was monitored by UV detection at 210 nm. This method allowed for the detection and quantification of R-THPA of levels at 0.5 and 1.5 μg/mL-1 resp. The method was validated following ICH guidelines.
Analytical Chemistry: An Indian Journal published new progress about HPLC chiral stationary phases. 192725-50-1 belongs to class pyrimidines, name is (S)-3-Methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoic acid, and the molecular formula is C9H16N2O3, Product Details of C9H16N2O3.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia