Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependent RNA polymerase: 2-Aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives was written by Rawal, Ravindra K.;Katti, S. B.;Kaushik-Basu, Neerja;Arora, Payal;Pan, Zhenhua. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Quality Control of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:
Hepatitis C virus (HCV) NS5B RNA polymerase is crucial for replicating the HCV RNA genome and is an attractive target for developing anti-HCV drugs. A novel series of 2,3-diaryl-1,3-thiazolidin-4-one derivatives were evaluated for their ability to inhibit HCV NS5B. Several compounds emerged as more potent, displaying over 95% inhibition of NS5B RNA polymerase activity in vitro. The two most active compounds exhibited an IC50 of 31.9 μM and 32.2 μM, resp., against HCV NS5B. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Quality Control of 4,6-Diphenylpyrimidin-2-amine).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Quality Control of 4,6-Diphenylpyrimidin-2-amine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia