Synthesis and characterization of antitubercular triazine-chalcone hybrid molecules was written by Rawat, Aman;Kaur, Atinder;Surjit;Kaur, Harpreet. And the article was included in Asian Journal of Chemistry in 2017.Category: pyrimidines This article mentions the following:
A series of 1,3,5-triazine-chalcone hybrid mols. I [R = H, MeO, C6H5-CH2-O, etc.], II [R = H, CN, Cl, etc.] and III [R = H, MeO, Cl, etc.] were synthesized and evaluated in-vitro for Mycobacterium tuberculosis H37Rv inhibitory potency using Alamar blue assay and the activity expressed as the min. inhibitory concentration (MIC) in μg/mL. The antitubercular activity screening data revealed that di-Ph propen-2-one and compound II [R = H] demonstrated comparatively the most potent inhibitory activity, with MIC value 1.6 μg/mL. Most of the compounds I, II and III displayed significantly promising activity. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Category: pyrimidines).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia