Regan, Collin F.; Pierre, Fabrice; Schwaebe, Michael K.; Haddach, Mustapha; Jung, Michael E.; Ryckman, David M. published the artcile< A facile synthesis of 5-halopyrimidine-4-carboxylic acid esters via a Minisci reaction>, Synthetic Route of 6554-61-6, the main research area is Minisci homolytic alkoxycarbonylation halopyrimidine; bromopyrimidinecarboxylate; pyrimidine halo Minisci homolytic alkoxycarbonylation.
This paper reports the synthesis of various 5-halopyrimidine-4-carboxylic acid esters via the Minisci homolytic alkoxycarbonylation of 5-halopyrimidines. The reaction was found to be highly regioselective, allowing the one-step synthesis of useful amounts (>10 g) of Et 5-bromopyrimidine-4-carboxylate where other methods proved difficult. Et 5-bromopyrimidine-4-carboxylate was used for the preparation of potent CK2 inhibitors including CX-5011. This work represents an interesting application of radical chem. for the preparation of pharmacol. active mols.
Synlett published new progress about Alkoxycarbonylation (Minisci homolytic). 6554-61-6 belongs to class pyrimidines, and the molecular formula is C4H2Cl2N2, Synthetic Route of 6554-61-6.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia