Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors was written by Reigan, Philip;Gbaj, Abdul;Stratford, Ian J.;Bryce, Richard A.;Freeman, Sally. And the article was included in European Journal of Medicinal Chemistry in 2008.Name: 5-Chloro-7H-pyrrolo[2,3-d]pyrimidine The following contents are mentioned in the article:
Thymidine phosphorylase (TP) is over-expressed in various tumor types and plays an important role in tumor angiogenesis, growth, invasion and metastasis. The enzymic activity of TP is required for the angiogenic effect of TP, therefore, inhibitors of TP are of significant interest in cancer chemotherapy. A series of xanthine oxidase (XO) activated prodrugs of known inhibitors of TP have been designed and synthesized with the ultimate intent of improving tumor selectivity and pharmacokinetic characteristics. These prodrugs were not inhibitors of TP, but were selectively oxidized by XO at C-2 and/or C-4 of the uracil ring moiety to generate the desired TP inhibitor. Mol. modeling of both the TP inhibitors and XO-activated prodrugs rationalized their binding in the active site of the human TP crystal structure. This study involved multiple reactions and reactants, such as 5-Chloro-7H-pyrrolo[2,3-d]pyrimidine (cas: 1041864-02-1Name: 5-Chloro-7H-pyrrolo[2,3-d]pyrimidine).
5-Chloro-7H-pyrrolo[2,3-d]pyrimidine (cas: 1041864-02-1) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 5-Chloro-7H-pyrrolo[2,3-d]pyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia