Proton and carbon-13 NMR study of substituted pyrimidines. I. Substituent effects in methylated and aminated derivatives was written by Riand, J.;Chenon, M. T.;Lumbroso-Bader, N.. And the article was included in Organic Magnetic Resonance in 1977.Reference of 1193-74-4 This article mentions the following:
Substituent effects of Me and NH2 groups on the chem. shifts of pyrimidine were studied by 1H and 13C NMR and compared with data obtained for C6H6 and pyridine. Chem. shifts calculated by the additivity relation agree with exptl. values except for hindered pyrimidines. The 13C NMR spectra of some trisubstituted pyrimidines were assigned. In the experiment, the researchers used many compounds, for example, 4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4Reference of 1193-74-4).
4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Reference of 1193-74-4
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia