Rode, W. published the artcileInhibition of mammalian tumor thymidylate synthetase by 5-alkylated 2′-deoxyuridine 5′-phosphates, Related Products of pyrimidines, the main research area is alkylated deoxyuridine phosphate tumor; thymidylate synthetase inhibition tumor.
Improved syntheses, based on Lewis acid-catalyzed nucleosidation, are described for the preparation of 5-alkyl-2′-deoxyuridines. These were converted to their 5′-phosphates with the use of wheat shoot phosphotransferase. The dUMP analogs 5-ethyl-dUMP [56576-83-1] and 5-propyl-dUMP [64374-82-9] were competitive vs. dUMP inhibitors of thymidylate synthetase [9031-61-2] purified from mouse L1210, Ehrlich ascites, and HeLa cells, the former being the stronger inhibitor. Both analogs bind cooperatively to each of the mouse tumor enzymes, 2 mols. of inhibitor interacting with a single enzyme mol., as reflected by the parabolic character of the replots of the slope vs. inhibitor concentrations DTMP [365-07-1] was a stronger inhibitor of the mouse tumor enzymes than its higher alkyl homologs.
Biochemical Pharmacology published new progress about Antitumor agents. 19030-75-2 belongs to class pyrimidines, name is 5-N-Propyluracil, and the molecular formula is C7H10N2O2, Related Products of pyrimidines.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia