Rosemeyer, Helmut; Kaiser, Klaus; Seela, Frank published the artcile< Dextran-linked 7-deazaguanine - a polymer-bound inhibitor of xanthine oxidase>, Related Products of 84955-32-8, the main research area is xanthine oxidase deazaguanine dextran inhibitor; immobilized deazaguanine xanthine oxidase inhibition.
Dextran-linked 7-deazaguanine as well as 7-deazahypoxanthine and allopurinol derivatives were prepared by carbodiimide condensation of the 2-carboxyethyl intermediates with N-(6-aminohexyl)carbamoylmethylated dextran T80. The dextran-linked bases are degradable by endo-dextranase (EC 3.2.1.11) as demonstrated by time-dependent viscosity measurements. Monomeric as well as polymer-linked purine analogs were tested as inhibitors of xanthine oxidase (EC 1.2.3.1) from cow’s milk. Whereas the allopurinol- and 7-deazahypoxanthine derivatives no longer bind to the enzyme, the 7-deazaguanine derivatives are strong competitive inhibitors of xanthine oxidase even in the polymer-linked state.
International Journal of Biological Macromolecules published new progress about Enzyme kinetics. 84955-32-8 belongs to class pyrimidines, and the molecular formula is C7H8N4O, Related Products of 84955-32-8.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia