《Extrusion of sulfur from [(acylmethyl)thio]pyrimidinones》 was written by Roth, Barbara; Laube, Renee; Tidwell, Mary Y.; Rauckman, Barbara S.. Category: pyrimidines And the article was included in Journal of Organic Chemistry on August 29 ,1980. The article conveys some information:
Thermally mediated S extrusion from the (phenacylthio)pyrimidinones I (R = H, R1 = Br, H, MeO; R = Me, R1 = Br) occurs rapidly in solution at 125° to yield the (benzoylmetheylene)pyrimidinones II. However, III rearranges via an episulfide intermediate to IV. Adjacent 3- or 5-Me substituents in the pyrimidine ring assist S extrusion. No reaction occurs in the absence of a 2-oxo function or on replacement of it by a 2-amino group. On the other hand, 2-amino-4[(1-methylacetonyl)thio]-6(1H)-pyrimidinone cyclizes very readily to give the thieno pyrimidinone V. 2-(Phenacylthio)-4(3H)-pyrimidinones lose S at about one-seventh the rate of the 4-phenacylthio isomers. No thermally mediated reaction occurs with 2-(acetonylthio)-4-pyrimidinones under the conditions described here. In the part of experimental materials, we found many familiar compounds, such as 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6Category: pyrimidines)
2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia