The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. HPLC of Formula: 109-12-6.
Rana, Bidyut K.;Roymahapatra, Gourisankar;Das, Himadri Sekhar;Giri, Santanab;Cardoso, Marlon H.;Franco, Octavio L.;Kiran, N. K.;Santra, Manas K.;Bag, Partha Pratim;Bertolasi, Valerio;Dinda, Joydev research published 《 Pyridine and pyrimidine functionalized half-sandwich Ru(II)-N heterocyclic carbene complexes: Synthesis, structures, spectra, electrochemistry and biological studies》, the research content is summarized as follows. New set of Ru-N-Heterocyclic Carbene (Ru-NHC) complexes 1a and 2a were synthesized from their ligand precursors 1-Methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate (1) and 1-Methyl-2-pyrimidin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate (2). The mols. were characterized and their structures were investigated through single crystals X-ray diffraction. The overall coordination around the Ru center can be described as a half-sandwich geometry. Absorption spectra and electrochem. behavior of the complexes were also evaluated, supported by DFT anal. The complexes were applied on lung (A549), colon (HCT116) and breast (MCF7) cancer cells to examine their in vitro cytotoxicity activity.
HPLC of Formula: 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia