Ruiz Ruiz, Maria del Carmen published the artcileThe ‘t-Amino Effect’ of ortho-nitroso amines. synthesis of 2,6-diaminoadenine derivatives from 6-(dialkylamino)-5-nitrosopyrimidines, Safety of 2-Amino-4,6-dichloropyrimidine, the publication is Helvetica Chimica Acta (2011), 94(5), 785-800, database is CAplus.
The ‘t-amino effect’ of amino-nitroso compounds was documented by preparing the (dialkylamino)-nitroso pyrimidines, and cyclising them under thermal conditions in high yields to the purine derivatives e. g., I(R1 = Me, R2 = H, Me, Pr, Ph; R1 = Et, R2 = Me; R1 = CO2Et, R2 = CH2CO2Et) and II. The reactivity of the amino-nitroso-pyrimidines, particularly of 17 derived from di-Et iminodiacetate, and of I(R1 = CO2Et, R2 = CH2CO2Et), derived from 1-phenylimidazolidine, correlates with the stability of the intermediate azomethine ylide. Thermolysis of the amino-nitroso-pyrimidines III(R1 = NO, R2 = 1-pyrrolidinyl, 1-piperidinyl, 1-morpholinyl, 4-Et isonipecotate-1yl) possessing dialkylamino substituents at C(4) and C(6), proceeded by protiodenitrosation, leading to III(R1 = H, R2 = 1-pyrrolidinyl, 1-piperidinyl, 1-morpholinyl, 4-Et isonipecotate-1yl).
Helvetica Chimica Acta published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Safety of 2-Amino-4,6-dichloropyrimidine.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia