On October 31, 2019, Rus, Lucia Maria; Donici, Elena; Valica, Vladimir; Prisacari, Viorel; Tomuta, Ioan; Sepeli, Diana; Heghes, Simona Codruta; Iuga, Cristina Adela; Uncu, Livia published an article.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Development, physical-chemical characterization and in vitro antibacterial activity evaluation of a fixed-dose combination isohydrafural-methyluracil hydrophilic ointment. And the article contained the following:
This research was focused on the pharmaceutical development of a novel, fixed-dose combination isohydrafural-methyluracil ointment on a water soluble base – polyethylene glycol (PEG). Differential scanning calorimetry (DSC) and Fourier transform infra-red spectroscopy (FTIR) were applied in order to determine the compatibility between active pharmaceutical ingredients (APIs) and between APIs – excipients. Nine formulations (F1 – F9) were tested for: phys. appearance and homogeneity, pH, viscosity and osmotic activity. The optimal formulation presented the concentrations of PEG 400 – 76.72%, PEG 1500 – 19.18% and a fixed-dose combination of 0.1% isohydrafural and 4% methyluracil. It showed higher antibacterial properties both to Gram-pos. and Gram-neg. bacteria than nitrofural 2% ointment (Furacilin, Belarus). The long-term stability testing of the optimized formulation of isohydrafural and methyluracil revealed the shelf-life of two years. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione
The Article related to staphylococcus enterococcus escherichia klebsiella pseudomonas proteus isohydrafural methyluracil antibacterial, Placeholder for records without volume info and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia