Ryabova, O. B.; Khmel’nitskaya, E. Yu.; Makarov, V. A.; Alekseeva, L. M.; Grigor’ev, N. B.; Granik, V. G. published their research in Russian Chemical Bulletin on December 31 ,2005. The article was titled 《4-[(Dialkylthiocarbamoyl)thio]-5-nitropyrimidines as new potential nitric oxide donors》.Name: 4-Chloro-6-methoxy-5-nitropyrimidine The article contains the following contents:
On heating at pH 6.86, the title compounds (I; X = H, Me; R = OMe, OPh, NHMe, NMe2, etc.; NR1R2 = 1-pyrrolidinyl, piperidino, hexahydro-1-azepinyl, NMeEt, etc.) are transformed into dithiolopyrimidines, which are either oxidized to bis(dialkylthiocarbamoylpyrimidin-5-yl) disulfides (II; n = 1, 2, 3) or converted to aminonitropyrimidines (III; n = 1, 2) with carbon disulfide elimination. The direction of the reaction is determined by the nature of the substituent in position 2 of the pyrimidine and the bulk of the thiocarbamate substituent. Mechanistic schemes for these processes are proposed. Refluxing most I in EtOH containing a phosphate buffer (pH 6.86) resulted in degradation to form nitrite anion, a measure of NO-donor ability. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5Name: 4-Chloro-6-methoxy-5-nitropyrimidine)
4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Name: 4-Chloro-6-methoxy-5-nitropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia