Rzasa, Robert M.; Hu, Essa; Rumfelt, Shannon; Chen, Ning; Andrews, Kristin L.; Chmait, Samer; Falsey, James R.; Zhong, Wenge; Jones, Adrie D.; Porter, Amy; Louie, Steven W.; Zhao, Xiaoning; Treanor, James J. S.; Allen, Jennifer R. published the artcile< Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux>, Related Products of 5018-38-2, the main research area is biaryl ether PDE10A inhibitor preparation Pgp efflux structure.
We report the discovery of a novel series of biaryl ethers as potent and selective PDE10A inhibitors. Structure-activity studies improved the potency and decreased Pgp-mediated efflux found in the initial compound 4. X-ray crystallog. studies revealed two novel binding modes to the catalytic site of the PDE10A enzyme.
Bioorganic & Medicinal Chemistry Letters published new progress about Antipsychotics. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, Related Products of 5018-38-2.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia