One-Pot Sequential Synthesis of 2-Amino-4,6-Diaryl Pyrimidines Involving SO3H-Functionalized Piperazinium-Based Dicationic Ionic Liquids as Homogeneous Catalysts was written by Saikia, Susmita;Borah, Ruli. And the article was included in ChemistrySelect in 2019.Related Products of 40230-24-8 This article mentions the following:
A new series of -SO3H functionalized dicationic ionic liquids based on N,N,N’,N’-tetrasulfopiperazinium cation [TSPi]+ and various anions [X]– (X = Cl, CF3SO3, TsO) was synthesized. Bronsted acidity of these ionic liquids was determined by Hammett plot using UV-Visible absorbance spectra. Further, they were examined as acidic catalysts for one-pot preparation of 2-amino-4,6-diarylpyrimidines I [R = H, 2-HO, 4-Cl, 2,4-Cl2, etc.] through Biginelli-like reaction of acetophenone, benzaldehydes and urea followed by a condensation-aromatization reaction with phenylhydrazine under solvent-free grinding method. The most acidic catalyst, [TSPi][CF3SO3]2, offered good to satisfactory yield within 15-25 mins reaction time. Easy recyclability and simple and mild reaction conditions represented the advantages of this method. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 40230-24-8
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia