Sakamoto, Takao; Ono, Takayasu; Sakasai, Takeji; Yamanaka, Hiroshi published an article on January 31 ,1980. The article was titled 《Studies on pyrimidine derivatives. XV. Homolytic acylation and amidation of simply substituted pyrimidines》, and you may find the article in Chemical & Pharmaceutical Bulletin.COA of Formula: C6H8N2O The information in the text is summarized as follows:
The reaction of 2,6-disubstituted pyrimidines with acyl radicals generated either from pyruvic acid-AgNO3-(NH4)2S2O8 or from aldehyde-FeSO4-Me3COOH in aqueous H2SO4, gave the corresponding 2,6-disubstituted 4-acylpyrimidines. 4,6-Disubstituted pyrimidines gave 2-acetyl- and 2,5-diacetyl-4,6-disubstituted pyrimidines under the same conditions. Homolytic amidation of pyrimidines in which the 2- or 4-positions are free yielded pyrimidine-2- or -4-carboxamides. The experimental process involved the reaction of 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6COA of Formula: C6H8N2O)
2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.COA of Formula: C6H8N2O
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia