On July 31, 2020, Sakata, Rina C.; Ishiguro, Soh; Mori, Hideto; Tanaka, Mamoru; Tatsuno, Kenji; Ueda, Hiroki; Yamamoto, Shogo; Seki, Motoaki; Masuyama, Nanami; Nishida, Keiji; Nishimasu, Hiroshi; Arakawa, Kazuharu; Kondo, Akihiko; Nureki, Osamu; Tomita, Masaru; Aburatani, Hiroyuki; Yachie, Nozomu published an article.COA of Formula: C5H6N2O2 The title of the article was Base editors for simultaneous introduction of C-to-T and A-to-G mutations. And the article contained the following:
Abstract: We describe base editors that combine both cytosine and adenine base-editing functions. A codon-optimized fusion of the cytosine deaminase PmCDA1, the adenosine deaminase TadA and a Cas9 nickase (Target-ACEmax) showed a high median simultaneous C-to-T and A-to-G editing activity at 47 genomic targets. On-target as well as DNA and RNA off-target activities of Target-ACEmax were similar to those of existing single-function base editors. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).COA of Formula: C5H6N2O2
The Article related to target acemax adenine guanine cytosine thymine mutation base editing, Biochemical Genetics: Gene Structure and Organization and other aspects.COA of Formula: C5H6N2O2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia