Saleh, Mohanad Y. et al. published their research in Journal of Nanostructures in 2022 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Formula: C16H13N3

Synthesis of some novel 1,8-naphthyridine chalcones as antibacterial agents was written by Saleh, Mohanad Y.;Al-Barwari, Alyaa S. M. O.;Ayoob, Alaa I.. And the article was included in Journal of Nanostructures in 2022.Formula: C16H13N3 This article mentions the following:

In this research SiO2 nanoparticles was applied for synthesis of some new 2-chloro-1,8-naphthyridine-3-carbaaldehyde through Vilsmeier-Haack cyclization of N-(pyridine-2-yl)acetamide has been reported and transformation to new chalcones containing morpholine ring from reaction of 2-morpholine-3-formyl-1,8-naphthyridine and 2-aminoacetophenone to produce E-3-(2-morpholino-1,8-naphthyridine3-yl)-1-(4-aminophenyl) prop-2-en-1-one through Claisen-Schmidt reaction by using (Nano silicon dioxide imidazolidin sulfite Pr silyl trifloroacetate) as catalyst. which on treatment with N-chloroacetyl-4,6- di-Ph pyrimidinyl amine gave compound I [X = N; R = 3,5-(Ph)2]. E-3-(2-morpholino-1,8-naphthyridine3-yl)-1-(4-aminophenyl)prop-2-en-1-one treated with chloro acetyl arylamine in presence of small amount of carbonate in DMF gave compound I [X = C; R = H] . The structures of the final compounds were confirmed by IR and 1HNMR. These compounds were evaluated for their antibacterial activity against gram pos. and gram-neg. bacteria using dilution procedure showed activity against the bacteria under study; 1,8-naphthyridine derivatives boost the fluoroquinolone antibiotics efficiency against multi-resistant bacteria and therefore appealing prospects for development of treatments against bacterial infections caused by multidrug-resistant strains. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia