In 2015,Samanta, Ramesh C.; Yamamoto, Hisashi published 《Selective Halogenation Using an Aniline Catalyst》.Chemistry – A European Journal published the findings.Electric Literature of C6H3Cl2N3 The information in the text is summarized as follows:
Electrophilic halogenation was used to produce a wide variety of halogenated compounds The arylamines were found to generate an N-halo arylamine intermediate, which acts as a highly reactive but selective catalytic electrophilic halogen source. A wide variety of heteroaromatic and aromatic compounds were halogenated using com. available N-halosuccinimides, for example, NCS, NBS, and NIS, with good to excellent yields and with very high selectivity. In the case of unactivated double bonds, allylic chlorides were obtained under chlorination conditions, whereas bromocyclization occurred for polyolefin. The reactivity of the catalyst could be tuned by varying the electronic properties of the arene moiety of catalyst. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Electric Literature of C6H3Cl2N3)
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Electric Literature of C6H3Cl2N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia