Efficient discovery of novel antimicrobials through integration of synthesis and testing in crude ribosome extract was written by Sang, Zitai;Lu, Yongping;Zhou, Yuanzheng;Ju, Yuan;An, Qi;Shen, Silan;Shi, Jianyou;He, Jun;Yang, Tao;Luo, Youfu. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.HPLC of Formula: 37972-24-0 This article mentions the following:
By coupling in situ [2+3] Huisgen cycloaddition with an in vitro transcription/translation luminescence assay in a crude ribosomal extract, a robust and accurate high-throughput platform was successfully developed and applied for efficient identification of novel structural types of ribosomal inhibitors with antimicrobial activity against drug-resistant bacteria. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0HPLC of Formula: 37972-24-0).
2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.HPLC of Formula: 37972-24-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia