Ab initio studies of the antiviral drug 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)thymine was written by Sapse, A. M.; Snyder, G.. And the article was included in Cancer Investigation in 1985.Recommanded Product: 69256-17-3 The following contents are mentioned in the article:
The antiviral drug 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)thymine (I) [69256-17-3] exhibits a high therapeutic index against a number of herpesviruses. As with other drugs which are nucleoside analogs, such as 1-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)-5-iodocytosine and others, the activity seems to be strongly related to the presence of a fluorine atom in the sugar moiety, in the arabino position. Theor. calculations, using quantum-chem. methods, are used to elucidate the role of the fluorine in the arabino position and to provide information about the sugar puckering. The results seem to indicate that the fluorine atom prevents the rotation of the base around the sugar-base bond, locking it into an anti-structure which might be related to its exposure to enzymic attack. The sugar study confirms the endo-position (above the plane) of the C’-2 carbon as opposed to the endo-position of the C’-3 carbon. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Recommanded Product: 69256-17-3).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Recommanded Product: 69256-17-3
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3