Evaluation of antivirals in preventing herpes simplex virus-induced cataracts in a murine model was written by Schinazi, Raymond F.; Scott, R. Taylor; Gammon, J. Allen; Stulting, R. Doyle; Kuck, John F. R.; Wright, John D.; Nahmias, Andre J.. And the article was included in International Congress Series in 1985.Formula: C10H13FN2O5 The following contents are mentioned in the article:
In mice inoculated intracerebrally with herpes simplex virus type 2, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine (FMAU) [69256-17-3] and FMAC [78636-53-0] treatment completely inhibited cataract formation; although acyclovir [59277-89-3], ara-A [5536-17-4], 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-S-iodocytosine (FIAC) [69123-90-6], and other drugs were effective in reducing mortality, they were unable to prevent cataractogenesis. Results on the optimization of virally-induced cataract formation and virol., immunol., and pathol. findings are presented. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Formula: C10H13FN2O5).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Formula: C10H13FN2O5
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3