Schinazi, Raymond F. published the artcileSynthesis of 5-(dihydroxyboryl)-2′-deoxyuridine and related boron-containing pyrimidines, Recommanded Product: 2,4,6-Tribromopyrimidine, the main research area is boryldeoxyuridine dihydroxy; uridine deoxy dihydroxyboryl; uracil dihydroxyboryl; virucide dihydroxyboryldeoxyuridine; neoplasm inhibitor dihydroxyboryldeoxyuridine.
Organoboron derivatives of pyrimidines and of 2′-deoxyribonucleosides were prepared as potential antiviral and anticancer agents. The title nucleoside (I) was prepared via a metal-halogen exchange at -50° in THF on 5-bromo-3′,5′-bis-O-(trimethylsilyl)-2′-deoxyuridine using BuLi followed by boronation at -65° with B(OBu)3 in the presence of HMPT. After hydrolysis, I was purified by column chromatog. and repeated fractional crystallization I was hydrolytically stable and showed no activity against Sarcoma 180 but inhibited herpes simplex virus type 1 at a nontoxic concentration I sensitized hamster V-79 cells to neutrons and could be of potential use in B neutron capture therapy. 5-(Dihydroxyboryl)uracil and 6-(dihydroxyboryl)uracil were similarly prepared The phys. characteristics of these analogs, as well as those of their iminodiethanol esters, are described.
Journal of Organic Chemistry published new progress about Antitumor agents. 36847-11-7 belongs to class pyrimidines, name is 2,4,6-Tribromopyrimidine, and the molecular formula is C4HBr3N2, Recommanded Product: 2,4,6-Tribromopyrimidine.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia