Schniewind, Inaki et al. published their research in Cell Reports in 2022 | CAS: 1373422-53-7

3-((2-(Pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid (cas: 1373422-53-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Application of 1373422-53-7

Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity was written by Schniewind, Inaki;Hadiwikarta, Wahyu Wijaya;Grajek, Julia;Poleszczuk, Jan;Richter, Susan;Peitzsch, Mirko;Mueller, Johannes;Klusa, Daria;Beyreuther, Elke;Loeck, Steffen;Luehr, Armin;Frosch, Susanne;Groeben, Christer;Sommer, Ulrich;Krause, Mechthild;Dubrovska, Anna;von Neubeck, Claere;Kurth, Ina;Peitzsch, Claudia. And the article was included in Cell Reports in 2022.Application of 1373422-53-7 The following contents are mentioned in the article:

Proton radiotherapy has been implemented into the standard-of-care for cancer patients within recent years. However, exptl. studies investigating cellular and mol. mechanisms are lacking, and prognostic biomarkers are needed. Cancer stem cell (CSC)-related biomarkers, such as aldehyde dehydrogenase (ALDH), are known to influence cellular radiosensitivity through inactivation of reactive oxygen species, DNA damage repair, and cell death. In a previous study, we found that ionizing radiation itself enriches for ALDH-pos. CSCs. In this study, we analyze CSC marker dynamics in prostate cancer, head and neck cancer, and glioblastoma cells upon proton beam irradiation We find that proton irradiation has a higher potential to target CSCs through induction of complex DNA damages, lower rates of cellular senescence, and minor alteration in histone methylation pattern compared with conventional photon irradiation Math. modeling indicates differences in plasticity rates among ALDH-pos. CSCs and ALDH-neg. cancer cells between the two irradiation types. This study involved multiple reactions and reactants, such as 3-((2-(Pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid (cas: 1373422-53-7Application of 1373422-53-7).

3-((2-(Pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid (cas: 1373422-53-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Application of 1373422-53-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia