On January 1, 2020, Semenov, Vyacheslav E.; Zueva, Irina V.; Lushchekina, Sofya V.; Lenina, Oksana A.; Gubaidullina, Lilya M.; Saifina, Lilya F.; Shulaeva, Marina M.; Kayumova, Ramilya M.; Saifina, Alina F.; Gubaidullin, Aidar T.; Kondrashova, Svetlana A.; Latypov, Shamil K.; Masson, Patrick; Petrov, Konstantin A. published an article.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was 6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: Reactivation for paraoxon-inhibited acetylcholinesterase. And the article contained the following:
New uncharged conjugates of 6-methyluracil derivatives with imidazole-2-aldoxime I (n = 1, 2, 3, 4) and 1,2,4-triazole-3-hydroxamic acid units II (n = 2, 3, 4) were synthesized and studied as reactivators of organophosphate-inhibited cholinesterase. Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. The reactivating efficacy of one compound II (n = 3) is lower than that of pyridinium-2-aldoxime (2-PAM). Meanwhile, unlike 2-PAM, in vivo study showed that the lead compound II (n = 3) is able: (1) to reactivate POX-inhibited AChE in the brain; (2) to decrease death of neurons and, (3) to prevent memory impairment in rat model of POX-induced neurodegeneration. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione
The Article related to methyluracil imidazole aldoxime triazole hydroxamic acid preparation mol docking, reactivator paraoxon acetylcholinesterase butyrylcholinesterase inhibitor, 3,6-dimethyluracil, acetylcholinesterase, hydroxamic acids, molecular modeling, paraoxon, reactivator and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia