Adding a certain compound to certain chemical reactions, such as: 6303-46-4, 6-Chloro-N-(3,4-dichlorophenyl)pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6303-46-4, blongs to pyrimidines compound. Computed Properties of C10H6Cl3N3
General procedure: 5.1.4 4-(6-{[4-(Trifluoromethyl)phenyl]amino}pyrimidin-4-yl)benzoic acid (4-1) 22 Under a nitrogen atmosphere, 6-chloro-N-[4-(trifluoromethyl)phenyl]pyrimidin-4-amine (3-1) (4.10 g, 10 mmol), 4-carboxyphenylboronic acid (2) (2.00 g, 12 mmol), Pd(PPh3)4 (0.60 g, 0.50 mmol) and Cs2CO3 (13.0 g, 30 mmol) were suspended in a mixture of CH3CN/H2O (100 mL, V:V = 1:1). The mixture was heated under reflux for 48 h at 90 C. The hot suspension was filtered and the filtrate distilled by rotary evaporation to remove acetonitrile. Water was added, and the mixture was extracted three times with EtOAc (3 * 30 ml). The aqueous layer was acidified with conc. HCl and extracted two more times with EtOAc. The combined organic layers were washed with brine and dried over Na2SO4. Evaporation of the solvent gave the crude product, which was purified by flash column chromatography to afford the product (2.90 g, 81%). The key intermediate Compounds (4-1) – (4-19) were preparedby using the general procedure described above.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6303-46-4, its application will become more common.
Reference:
Article; Dong, Jinyun; Lu, Wen; Pan, Xiaoyan; Su, Ping; Shi, Yaling; Wang, Jinfeng; Zhang, Jie; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6876 – 6884;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia