Adding a certain compound to certain chemical reactions, such as: 428854-24-4, 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, blongs to pyrimidines compound. name: 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine
B, to 500 ml reaction vial the adding step a 29.0g (0.083mol) compound 3,150 ml methanol, 9.7g (0.1mol) carbonic acid dimethyl ester (compound 4), in 30 C stirring reaction under 6h; after the reaction, the obtained reaction solution in the 50 C, vacuum 0.09 MPa reducing pressure and evaporating the solvent, the residue obtained by adding 150 ml ethyl acetate stirring 15 min, filter, the filtration cake at the 65 C, vacuum 0.09 MPa dry the 5h, to obtain 4,6-diamino-2 – [1 – (2-fluorobenzyl) – 1H-pyrazolo [3,4-b] pyridin-3-yl] – 5-pyrimidinyl amino a acid methyl ester (compound 5) 29.8g (yield 88%);
The synthetic route of 428854-24-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Drug Technology Co., Ltd.; Mao, Ying; Bi, Tianhao; Li, Jinhua; Liu, Zhiqing; Lou, Lili; Zhang, Jiamei; (11 pag.)CN105294686; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia