Reference of 945950-37-8, Adding some certain compound to certain chemical reactions, such as: 945950-37-8, name is 4-Methyl-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C7H7N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 945950-37-8.
General procedure: To a mixture of appropriate 3a-e (1.5 mmol), 1 (1.57 mmol) and Ph3P (3.75 mmol) in THF was added DIAD (3.75 mmol) dropwise at 0 C under nitrogen and stirring continued at rt. Completion of reaction was analyzed by TLC, solvent evaporated under reduced pressure and crude was purified by column chromatography on silica gel by eluting up to 30 % ethyl acetate in hexane to give couple products in more than 80 % yield. The deprotection was carried out by heating at 60 C in 10 % HCl in MeOH. After completion (monitored by TLC), the reaction mixture was neutralized by NaHCO3 and purified by silica gel chromatography (10% methanol in DCM) to get 6a-e in 70-85% yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 945950-37-8, 4-Methyl-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Thiyagarajan, Anandarajan; Salim, Mohammed T.A.; Balaraju, Tuniki; Bal, Chandralata; Baba, Masanori; Sharon, Ashoke; Bioorganic and Medicinal Chemistry Letters; vol. 22; 24; (2012); p. 7742 – 7747;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia