Reference of 330786-24-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 330786-24-8 as follows.
[0143] To a stirred solution of 1-2 (0.15 g, 0.5 mmol) inDMF (3.0 mL) 1-12 (0.2 g, 0.54 mmol) and Cs2C03 (0.32 g,1.0 mmol) is added. The reaction mixture is heated to 60 C. After 18 hours, the reaction mixture is concentrated in vacuoand purified via Combi-flash chromatography on silica gel(using a solvent gradient of 5% MeOH in CH2Cl2 ) to afford1-13 (0.18 g, 73%). The following intermediate was preparedin similar fashion:
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,330786-24-8, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOSANAC, Todd; DISALVO, Darren; HORAN, Joshua Courtney; LIANG, Shuang; ZINDELL, Renee M.; US2014/275014; (2014); A1;,
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