Electric Literature of 4595-61-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4595-61-3 as follows.
Pyrimidine-5-carbonyl chloride hydrochloride 7.50 g (60 mmol) pyrimidine-5-carboxylic acid are stirred in 50 ml of thionyl chloride and 0.5 ml dimethylformamide for 4 hours at 70° C. The reaction mixture is evaporated to dryness and re-evaporated several times with toluene. Yield: 7.80 g (72percent of theoretical)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4595-61-3, its application will become more common.
Reference:
Patent; Maier, Udo; Grauert, Matthias; Hoffmann, Matthias; Hoenke, Christoph; Joergensen, Anne T.; Pautsch, Alexander; Brandl, Trixi; Breitfelder, Steffen; Scheuerer, Stefan; Erb, Klaus; Pieper, Michael; Pragst, Ingo; US2007/259855; (2007); A1;,
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