Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 69034-12-4, name is 2-Chloro-5-(trifluoromethyl)pyrimidine. A new synthetic method of this compound is introduced below., Recommanded Product: 2-Chloro-5-(trifluoromethyl)pyrimidine
STEP 2A: 2-[(3R)-3-METHYLPIPERAZIN-1-YL]-5-(TRIFLUOROMETHYL)PYRIMIDINE (0208) To a solution of tert-butyl (2R)-2-methylpiperazine-l-carboxylate (2.2 g, 11.0 mmol, 1.0 eq) and 2-chloro-5-(trifluoromethyl)pyrimidine (2.0 g, 11.0 mmol, 1.0 eq) in 1 -methyl-2-pyrrolidone (NuMuRho,IotaOmicron mL) was added N^V-diisopropylethylamine (5.7 mL, 44.0 mmol, 4.0 eq) and the reaction mixture heated to 100 C for 1 hr. The reaction mixture was cooled, diluted heavily with EtOAc, and washed repeatedly with brine (5x). The organic layer was dried over Na2SC>4 and concentrated. Silica gel column (80 g) was loaded using methylene chloride and run using an increasing gradient of EtOAc (5-90%) in hexanes over 20 min. The chromatographed material was dissolved in dioxane (25 mL) and treated with a solution of 4M HC1 in dioxane (6 mL). The resulting thick white suspension was concentrated, dissolved in MeOH, and made basic with the addition of MP-carbonate. Following removal of the resin and concentration of the filtrate, the free base of 2-[(3R)-3-methylpiperazin-l-yl]-5- (trifluoromethyl)pyrimidine 2a (1.9 g, 7.6 mmol, 69% over two steps) was isolated as a white solid.
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Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; HARRIOTT, Nicole; PAGANO, Nicholas; (135 pag.)WO2017/79641; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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