Application of 1192711-37-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1192711-37-7 as follows.
Carboxylic acid 1.6 (3.15g, 15 mmol) was dissolved in N ,N- dimethylformamide (70 mL) and treated with HOBt (3.13g, 23 mmol) and EDC (4.4g, 23 mmol). After stirring ca. 25 min ammonia (0.5 M in 1,4-dioxane, 72 mL, 36 mmol) was added and the reaction stirred overnight. The following morning the reaction was diluted with water to a total volume of 500 mL and the desired product collected by filtration affording 3.62g (74%) of a light-beige solid. 1H NMR (DMSO-d6, 400 MHz): delta 9.30 (d, IH), 8.54 (s, IH), 8.15 (d, IH), 8.09 (s, IH), 7.74 (d, IH), 7.64 (m, 2H), 7.51 (t, IH), 3.77 (m, IH), 1.79 (m, 2H), 1.74 (m, 2H), 1.53 (m, IH), 1.41 (m, IH).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1192711-37-7, its application will become more common.
Reference:
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2009/131687; (2009); A2;,
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