Reference of 33034-67-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine, molecular formula is C5H2ClF3N2, molecular weight is 182.531, as common compound, the synthetic route is as follows.
To a mixture was sodium hydride (9 mg, 60percent dispersion) in 5 ml of dimethylformamide was added 4-(5-cyano-7-isopropyl-l,3-benzoxazol-2-yl)-N-[(5-methyl-2-oxo-l,3-oxazolidin-5- yl)methyl]benzamide (31 mg, EXAMPLE 65) followed by 2-chloro-4-trifluoromethylpyrimidine (14 mg). The mixture was stirred at 700C for 1 h. Excess sodium hydride was quenched by addition of 1 ml of methanol. The sample was then purified via mass-directed HPLC on a Kromasil Cl 8 column eluting with a gradient of 10percent acetonitrile in water (0.01percent TFA) to 60percent acetonitrile in water (0.01percent TFA) providing the title compound (25 mg, 59percent).
Statistics shows that 33034-67-2 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-(trifluoromethyl)pyrimidine.
Reference:
Patent; MERCK & CO., INC.; WO2008/156718; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia