Reference of 26452-81-3, Adding some certain compound to certain chemical reactions, such as: 26452-81-3, name is 4-Chloro-6-methoxypyrimidine,molecular formula is C5H5ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26452-81-3.
To a mixture of 1.5 g of 4-chloro-6-methoxypyrimidine, 1.2 mL of 2,2,3,3,3-pentafluoro-1-propanol and 10 mL of DMF,Under ice-cooling, 0.5 g of sodium hydride (oil, 60%) was added.The resulting mixture was stirred at 80 C. for 5 hours. Water was added to the resulting reaction mixture, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine,Dry over anhydrous sodium sulfate and concentrate under reduced pressure.The obtained residue was subjected to silica gel chromatography to obtain 1.78 g of Intermediate 2-8 shown below.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 26452-81-3, 4-Chloro-6-methoxypyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; MURAKAMI, SHINICHIRO; (291 pag.)JP2018/76354; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia