Reference of 22536-66-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 22536-66-9, name is 2-Chloropyrimidine-4-carboxamide. A new synthetic method of this compound is introduced below.
General procedure: Aryl Halide, tetrakis (triphenylphosphine)palladium or Palladium(II) bis(triphenylphosphine) dichloride (0.05 eq) and boronic acid orpinnacol ester (1.2 eq) were weighed out into a microwave vessel or sealed tube. Acetonitrile (3 mL/mmol) and a 1M aqueous solutionof Sodium Carbonate (3 eq) were added. The vessel was capped and heatedthermally3-18 hrs at 100 C. Upon completion, the reaction was cooled and crudeproduct was either triterated via addition of water and collection byfiltration or extracted with sat ammonium chloride and DCM. If the crudeproduct was an intermediate, it was taken into the next step in most cases w/ofurther purification or alternatively submitted for reverse phase HPLCpurification when it was a final product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,22536-66-9, 2-Chloropyrimidine-4-carboxamide, and friends who are interested can also refer to it.
Reference:
Patent; Genentech, Inc.; Blaquiere, Nicole; Castanedo, Georgette; Feng, Jianwen A.; Hu, Baihua; Staben, Steven; Yuen, Po-wai; Wu, Guosheng; Lin, Xingyu; Burch, Jason; US2015/57260; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia