Electric Literature of 75833-38-4, Adding some certain compound to certain chemical reactions, such as: 75833-38-4, name is 2-Chloropyrimidine-4-carbonitrile,molecular formula is C5H2ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75833-38-4.
General procedure: (2S)-N-(1-((3,3-difluorocyclobutyl)carbamoyl)-2,3-dihydro-1H-inden-1-yl)-N- (5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide (100 mg, 0.21 mmol), 2-chloroisonicotinonitrile( 29 mg, 0.21 mmol), Cs2CO3( 137 mg, 0.42 mmol), Pd2(dba)3(19 mg, 0.021 mmol) and Xant-Phos(24 mg, 0.042 mmol) was stirred under N2 at 90oC overnight. After filtration, the filtrate was concentrated in vacuo and the residue was purified by Pre-HPLC(base) to obtain two diastereoisomers as (S)-1-(4-cyanopyridin-2-yl)-N-((S)-1-((3,3-difluorocyclobutyl) carbamoyl)-2,3-dihydro-1H-inden-1-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide (1b, 10 mg, 9% yield) and (S)-1-(4-cyanopyridin-2-yl) -N-((R)-1-((3,3-difluorocyclobutyl) carbamoyl)-2,3-dihydro-1H-inden-1-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2- carboxamide as white solid(1b?, 12 mg10% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 75833-38-4, 2-Chloropyrimidine-4-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Zheng, Qiangang; Tang, Shuai; Fu, Xianlei; Chen, Ziqi; Ye, Yan; Lan, Xiaojing; Jiang, Lei; Huang, Ying; Ding, Jian; Geng, Meiyu; Huang, Min; Wan, Huixin; Bioorganic and Medicinal Chemistry Letters; vol. 27; 23; (2017); p. 5262 – 5266;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia