Electric Literature of 69034-12-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.69034-12-4, name is 2-Chloro-5-(trifluoromethyl)pyrimidine, molecular formula is C5H2ClF3N2, molecular weight is 182.531, as common compound, the synthetic route is as follows.
General procedure: To a solution of 25a (200 mg, 0.458 mmol) in NMP (4 ml)was added 2-chloro-5-(trifluoromethyl)pyrimidine (100 ng,0.549 mmol) and K2CO3 (189 mg, 1.374 mmol) at room temperature.The reaction mixture was heated at 90 C for 3 h. After cooling to room temperature, the reaction mixture was diluted with water.The aqueous layer was separated and then extracted with EtOAc. The combined organic extracts were washed with water and brine,dried over Na2SO4, filtered, and concentrated. The residue was purified by flash column chromatography (silica gel: CHCl3/MeOH = 95/5) to afford 26a
Statistics shows that 69034-12-4 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-5-(trifluoromethyl)pyrimidine.
Reference:
Article; Tsuno, Naoki; Yukimasa, Akira; Yoshida, Osamu; Suzuki, Shinji; Nakai, Hiromi; Ogawa, Tomoyuki; Fujiu, Motohiro; Takaya, Kenji; Nozu, Azusa; Yamaguchi, Hiroki; Matsuda, Hidetoshi; Funaki, Satoko; Yamanada, Natsue; Tanimura, Miki; Nagamatsu, Daiki; Asaki, Toshiyuki; Horita, Narumi; Yamamoto, Miyuki; Hinata, Mikie; Soga, Masahiko; Imai, Masayuki; Morioka, Yasuhide; Kanemasa, Toshiyuki; Sakaguchi, Gaku; Iso, Yasuyoshi; Bioorganic and Medicinal Chemistry; vol. 25; 7; (2017); p. 2177 – 2190;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia