Adding a certain compound to certain chemical reactions, such as: 108381-23-3, Ethyl 2-chloro-4,6-dimethylpyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Ethyl 2-chloro-4,6-dimethylpyrimidine-5-carboxylate, blongs to pyrimidines compound. Safety of Ethyl 2-chloro-4,6-dimethylpyrimidine-5-carboxylate
General procedure: To a solution of appropriate 10 (0.5 g, 2.56 mmol) in dry CH3CN (30 ml), dry K2CO3 (1.06 g, 7.69 mmol) and propargyl alcohol (0.2 ml, 3.84 mmol) were added in that sequence and reaction mixture was refluxed overnight. After completion of reaction (TLC), CH3CN was removed under vacuum. Water was then added to the residue and the product extracted with DCM (2 x 20 ml). Solvent was removed to obtain crude 11, which was purified by column chromatography over silica 60-120 using 20:80 (ethyl acetate/hexane) as eluent to isolate analytically pure 11a-f.
The synthetic route of 108381-23-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chopra, Rakesh; De Kock, Carmen; Smith, Peter; Chibale, Kelly; Singh, Kamaljit; European Journal of Medicinal Chemistry; vol. 100; 1; (2015); p. 1 – 9;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia