As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4983-28-2, name is 2-Chloro-5-hydroxypyrimidine, molecular formula is C4H3ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Chloro-5-hydroxypyrimidine
Potassium carbonate (1.51g, 11 mmol) was slowly added to a stirred solution of 2- chloropyrimidin-5-ol (0.58g, 4.4 mmol) in DMF (25mL) followed by the addition of 3- (bromomethyl)-2,4-difluoro-l,5-dimethoxybenzene (Example 506, step (b)) (1.2g, 4.4 mmol) at 0 °C. The reaction mass was stirred at room temperature for 12h. Then the reaction mixture was quenched with ice cold water. The solid separated and was filtered and dried under reduced pressure to afford desired title compound (1.2g, 85percent). LCMS: m/z = 316.9 (M+H)+.
With the rapid development of chemical substances, we look forward to future research findings about 4983-28-2.
Reference:
Patent; EISAI R & D MANAGEMENT CO., LTD.; REYNOLDS, Dominic; HAO, Ming-Hong; WANG, John; PRAJAPATI, Sundeep; SATOH, Takashi; SELVARAJ, Anand; (128 pag.)WO2016/164703; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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