With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1053228-29-7, name is 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H2Cl2FN3, molecular weight is 206.01, as common compound, the synthetic route is as follows.Computed Properties of C6H2Cl2FN3
To a solution of 2,4-dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine (2.5 g, 12.14 mmol) in DMF (25 mL) was added NaH (582 mg, 14.57 mmol) at 0C. The mixture was stirred at this temperature for 1 h, and then SEM-C1 (2.43 g, 14.57 mmol) was added dropwise at 0C. The resulting mixture was stirred at 25C for 1 h. The reaction was slowly poured into ice-water, and then extracted with EtOAc (3 chi 80 mL). The combined organic phase was washed with brine (50 mL), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to give 2,4-dichloro-5-fluoro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine (2.5 g, 61.24% ) as a yellow oil. LCMS: RT 0.975 mm . m/z = 336.1 i H | .
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1053228-29-7, 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; DENALI THERAPEUTICS INC.; ESTRADA, Anthony A.; FENG, Jianwen A.; LYSSIKATOS, Joseph P.; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (271 pag.)WO2017/87905; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia