Electric Literature of 1208901-69-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1208901-69-2, name is 2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.
[0076] To the mixture of 2,4-dichloro-5 ,6,7, 8-tetrahydropyrido[4,3 -d]pyrimidine (2.20 g, 9.15 mmol, HC1 salt) in CH2C12 (30.00 mL) was added dropwise TEA (2.78 g, 27.45 mmol, 3.81 mL) at 0 C. Then the mixture was stirred under N2 at 0 C for 5 mm. To the mixture was added 2-methylpropanoyl chloride (1.17 g, 10.98 mmol, 1.15 mL) at 0 C. The mixture was stirred under N2 at 0 C for 2 h. LCMS showed one main peak of desired product. TLC (petroleum ether/EtOAc=1:1, Rf=0.6) showed one new main spot. The mixture was diluted with CH2C12 (40 mL) and washed with water (40 mLx2), citric acid (10%, 40 mLx3), sat.NaHCO3 (40 mLx2), brine (40 mL). The organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure to afford the title compund (2.50 g, crude) as a light yellow solid which was used in the next step without further purification. ?H NIVIR (400 IVIHz, DMSO-d6) oe 4.67-4.59 (m, 2H), 3.85-3.79 (m, 2H), 3.03-2.99 (m, 2H), 2.89-2.85 (m, 1H), 1.04 (d, J 6.4 Hz, 6H).
According to the analysis of related databases, 1208901-69-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KADMON CORPORATION, LLC; OLSZEWSKI, Kellen; POYUROVSKY, Masha; BARSOTTI, Anthony; KIM, Ji-In; LIU, Kevin; MORRIS, Koi; (143 pag.)WO2016/210331; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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