Synthetic Route of 1211443-61-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1211443-61-6 as follows.
A mixture of 2-chloro-7-cyclopentyl–N, N- dimethyl -7H- pyrrolo [2,3-d] pyrimidine-6-carboxamide (200mg, 0.68mmol), 5- (2- oxazolyl -7- aza-spiro [3.5]Nonane-1-yl) -2-amino-pyridine (0.17g, 0.78mmol), Cs2CO3 (0.20g, 1mmol), BINAP (20mg, 0.03mmol) andPd (OAc) 2 (10mg, 0.03mmol) was added mixed in 1,4-dioxane (30mL), purged with N2 at 95 react overnight.The reaction solutionAfter cooling, water was added (20 mL), and extracted with dichloromethane (40mL × 3), the organic phase was washed with water (15mL) washed with saturated brine (15mL) wash,Dried over anhydrous sodium sulfate, filtered, concentrated and the crude product is purified by silica gel column chromatography (methylene chloride / methanol (V / V) = 20/1), with methanolRecrystallized yellow solid (50mg, 15.4%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1211443-61-6, its application will become more common.
Reference:
Patent; East Sunshine Pharmaceutical Co., Ltd.; Liu, Bing; Zhang, Yingjun; Nie, Linlin; Bai, Shun; Zheng, Changchun; Nie, biao; Li, Zhiyong; Tan, Yumei; (61 pag.)CN105294737; (2016); A;,
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