Related Products of 1436686-17-7 ,Some common heterocyclic compound, 1436686-17-7, molecular formula is C9H8BrN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 0.28 g (1 .14 mmol) of compound 1-2 in 1.5 mL of EtOH were added 0.31 g (1 .14 mmol) of compound 2-2 and 0.026 g (0.23 mmol) of TFA at room temperature. The mixture in a sealed tube was stirred at 90 C overnight under N2atmosphere and cooled to rt. It was diluted with 10 mL of ethyl acetate and 50 mL of water, and extracted with three 50 mL portions of ethyl acetate. The combined organic extracts were washed with brine, and dried over anhydrous Na2S04. After filtration, the filtrate was concentrated to afford a residue, which was purified by chromatography on silica gel column eluted with 50% of ethyl acetate in petroleum ether to afford compound 1-3. LC-MS: m/e = 435 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1436686-17-7, its application will become more common.
Reference:
Patent; ANGEX PHARMACEUTICAL, INC.; WU, Wen-Lian; YANG, Zhiqiang; LEE, Francis; TAN, John Qiang; (112 pag.)WO2019/94143; (2019); A1;,
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