In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16462-27-4, name is 2,4-Diaminopyrimidine-5-carbonitrile, the common compound, a new synthetic route is introduced below. Formula: C5H5N5
To a suspension of 2,4-diaminopyrimidine-5-carbonitrile (2) (0.41 g, 2 mmol) in MeOH (20 mL) was added Nickel (0.13 g, 2 mmol) under H2, and the mixture was at 25 C stirred for 24 h. Then the reaction mixture was filtered, the filtrate was removed under reduced pressure and the residue was dissolved in water, then the aqueous solution was extracted with ethyl acetate (50 mL 3). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate and concentrated to give the crude product, which was purified by column chromatography to give 2,4-diaminopyrimidine-5-carbaldehyde (3) (0.22 g, 80% yield) as a white solid.
The synthetic route of 16462-27-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chen, Wenhua; Yao, Xue; Huang, Zhenghui; Mao, Fei; Guan, Longfei; Tang, Yun; Jiang, Hualiang; Li, Jian; Huang, Jin; Jiang, Lubin; Zhu, Jin; Chinese Chemical Letters; (2019); p. 250 – 254;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia