Application of 33034-67-2 ,Some common heterocyclic compound, 33034-67-2, molecular formula is C5H2ClF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 5:1′-(Pyridin-3-yl)-1-[4-(trifluoromethyl)pyrimidin-2-yl]-1H,1’H-3,4′-bipyrazoleUnder argon, 1′-(pyridin-3-yl)-1H,1’H-3,4′-bipyrazole (200 mg, 0.94 mmol) was initially charged in dimethylamide.Sodium hydride (56.8 mg, 1.42 mmol, 60percent in paraffin oil) was added, and the mixture was stirred at room temperature for 30 min (slightly exothermic).2-Chloro-4-trifluoromethylpyrimidine (173 mg, 0.94 mmol) was added, and the mixture was stirred at 40 C overnight.The mixture was then concentrated, and the residue was triturated with dichloromethane.Yield: 240 mg (71percent of theory), logP(HCOOH) 2.15, [M++1] 358.11H-NMR (d6-DMSO): 7.00 (m, 1H), 7.56 (m, 1H), 7.90 (d, 1H), 8.31 (m, 2H), 8.56 (m, 1H), 8.73 (m, 1H), 9.10 (s, 1H), 9.17-9.22 (m, 2H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33034-67-2, 2-Chloro-4-(trifluoromethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Bayer CropScience AG; US2011/166143; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia